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Non-small cell lung cancer (NSCLC) accounts for ~85% of all lung cancers, and includes two major histologic subtypes: adenocarcinoma (ADC) and squamous cell carcinoma (SCC) (1).
Very few cases were upgraded to cancer by the panel (5 CIN3 and 1 AIS to SCC; 1 CIN1 and 3 AIS to ADC).
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In achalasia patients, it has been suggested that chronic food stasis leads to chronic inflammation, epithelial hyperplasia, multifocal dysplasia, and squamous cell carcinoma (SCC) [ 1, 16, 17].
Oral cancer ranks sixth among the malignancies in terms of worldwide prevalence, with more than 90% being pathologically squamous cell carcinoma (SCC) [1].
On the other hand, several chemotherapeutic agents may be effective in the treatment of locally advanced or recurrent penile SCC [1], [6].
Differentiated (simplex) VIN is classified as high-grade VIN (thus VIN 3) due to its associated high risk to progress into invasive SCC [ 1, 4].
Actinic keratosis (AK) represents an early or in situ SCC [ 1, 2].
Myeloma is one of the most common malignant diseases leading to malignant spinal cord compression (SCC) [ 1, 2].
Basal cell carcinoma (BCC) is the most common form of skin cancer followed by squamous cell carcinoma (SCC) [ 1, 2].
Because different primary tumors have different biological behavior, it is important to have a specific survival score for each tumor entity associated with SCC [ 1, 2].
However, the finding that two LacI::GFP foci could be resolved in ∼89% of pachytene nuclei of kleisin triple mutants with wild-type levels of SCC-1 demonstrates that, unlike SCC mediated by REC-8 or COH-3/4 cohesin, SCC mediated by SCC-1 cohesin is insufficient to maintain the close association of sisters along their entire lengths.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com