A role for scavenger-type receptors (SR) in AM uptake of components of ROFA and CAP was identified by marked inhibition of RAS increases in AM pretreated with the specific SR inhibitor polyinosinic acid.
Yang et al.8 found that biomimetic synthetic HDL nanostructures targeted scavenger receptor type B-1 and induced apoptosis in B-cell lymphoma in mice.
Scavenger receptor type 1. Tumor-associated macrophages.
Perhaps equally important, HPPS mimics the functions of plasma-derived HDL in its pharmacokinetics and targeting specificity against scavenger receptor type B1 (SR-BI), which permits excellent delivery of the nanoparticle cargo to the target cells.
Overall, alternatively activated macrophages are efficient phagocytic cells with the expression of mannose and galactose receptors; CD163, TLR8, TLR1, and IL21a; and MRC1 and scavenger receptor type 1 (SR-A1) [17],[18],[20].
We confirmed the presence of mature macrophages in cell culture, by staining for specific markers F4/80 and scavenger receptor type III (CD204) in flow cytometry and immunofluorescence analysis (Figure 7E G).
Cholesterol efflux is regulated by various intracellular transporters, such as ATP binding cassette transporter proteins A1 ABCA1) and G1 (andG1) and scavenger receptor type B1 (SR-B1).
Then, we measured whether CWE affects gene expression of the scavenger receptors, type 1 macrophage scavenger receptor (SRA) and CD36, and the macrophage-specific integrin, CD11b using real-time PCR.
Also, the calcium-binding chaperone calreticulin was shown to induce a TH2 response and at the same time interact with the mammalian scavenger receptor type A on DCs [ 107].
A number of AGE-binding proteins have been identified, including macrophage scavenger receptors type I and II, oligosaccharyltransferase-48 (AGE-R1), 80K-H phosphoprotein (AGE-R2), galectin-3, CD36, LOX-170 and RAGE (Vlassara and Bucala 1996).
