For the main experiment, after discarding the first six images of each scanning run to allow for magnetic saturation effects, the remaining images were realigned, and then co-registered with the structural scans of the individual participants.
This concordance suggests that the deep mutational scanning effectively captures many of the structural and functional constraints on HA. 10.7554/eLife.03300.011 Figure 5.
For application to EINECS, the structural alerts (Table 2) have been implemented in a computerized screening tool (EDC-Scan).1 To support prediction confidence of the structural alerts in EDC-Scan, their applicability domain (AD) was defined based on atom-centered fragments (ACFs) [32].
These approaches and their results are discussed and compared with methods that afford quantitative structural comparisons without direct superposition, with special emphasis on the need for efficient automated methods suitable for rapid scans of large structural data bases.
SD participated in the laser scan analysis and performed parts of the structural assessment.
An additional consideration relates to how the diffusion image is spatially co-registered to the segmentations of the structural scan, which is itself not a trivial process, and can introduce further partial voluming if not done accurately [ 42, 43].
Structural scans of the brain were acquired for each participant using a T1-weighted three-dimensional sagittal magnetisation-prepared rapid gradient echo sequence with the following parameters: 176 slices, repetition time = 1900 ms, echo time = 2.93 ms, slice thickness = 1 mm, and an in-plane resolution of 0.508 × 0.508 mm.
MRI structural scans of the brain were obtained for coregistration purposes.
Applying wide-angle X-ray scattering method, thermomechanical analysis, and differential scanning calorimetry, the structural organization and properties of nanocomposites formed by chemical reduction of Сu2+ cations in the interpolyelectrolyte metal complex (pectin Cu2+ polyethyleneimine) under the influence of a constant magnetic and electric fields have been studied.
Once children had passed the mock scanner training protocol, there were no age related differences with respect to quality of the structural MRI scans.
