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Scanning, timing, and collection systems used were based on designs reported previously [ 30].
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The technical capabilities of modern CT equipment allow and require precise scan timing to synchronize data acquisition with the desired phase of vascular enhancement (for CTA) and parenchymal enhancement (for liver and pancreatic CT).
The scan timing should be confirmed to ensure it is within the specified acceptable window as per the protocol.
Two methods commonly used to provide accurate CTA scan timing are the test bolus and bolus tracking methods.
These differences mean that the same scan timing delay cannot be used for everyone, and it needs to be tailored to the individual.
The patient was injected with 0.7 g/kg iodine for 30 s, and the scan timing was 90 s after the injection.
Timing for the two scans differed by more than 20 min for three patients in the AI group, but in each case, scan timing would not have influenced early response classification (for example, one patient had a baseline SUV of 4.4 at 67.5 min and a post-therapy SUV of 3.8 at 45 min after injection. Any adjustment based on uptake time would attenuate the 14% decline toward 0%).
First, scan timing was determined by administering additional 10 mL of diluted (40/60 contrast/saline ratio) iodine contrast.
Functional data sets were then preprocessed; steps included rigid-body motion correction, slice scan timing correction, linear trend removal, and high pass filtering (3 cycles per series cutoff).
Scan timing parameters, therefore, ranged as follows: TR=8.8 11.1 ms; TE=4.2 ms fractional; flip=30°; temporal resolution=10.5 14.5 s; 35 time points per slice; scan time=6 min 8 s to 8 min 28 s.
Therefore, scan timing in relation to the administration of the drugs in each cycle, and the number of cycles after which the "early" response assessment is made, may both be important.
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