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The diffusion coefficients estimated using the proposed approach are compared with those determined using direct scanning of the parameter space as the optimization approach.
The scanning of the parameter space can be bounded by the availability of good measurements for at least some of the parameter values.
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In order to proceed with such a fitting method, the starting parameters must thus be accurately determined first by a systematic, well-sampled rough scan of the parameter space.
We reached this conclusion after a scan of the parameter range which is biologically relevant (according to literature), and also complies with these constraints.
The model parameters given in the caption of figure 4 represent the calibration result of a systematic scan of the parameter space, during which group motion was simulated with parameter values from reasonable ranges, identifying the parameter combination that generated the best agreement with the empirical observations.
Because values for the kinetic orders have a limited range of permissible values, after normalization of the rate constants, one can do a fairly comprehensive scan of the parameter values for the alternative networks and characterize the most relevant behaviors associated with each topology.
The stability of trailing bunch parameters after acceleration is tested employing a systematic scan of the parameters of the bunches at the injection.
In the general case, it uses a Monte Carlo scanning of the design parameters with different levels of adaptability.
In addition the software tool Copasi was used to perform some of the parameter scans and steady state examinations of the model [ 79].
ML-Space model interpreter and simulator are implemented in JAVA and integrated into the modeling and simulation framework JAMES II [ 64], which also served as experimental framework for most of the parameter scan experiments.
If no topology can reproduce experimental results over the entire range of scanned parameter values one can calculate the percentage of the parameter space in which the experimental behavior is qualitatively reproduced.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com