However when applied in vivo with μPET scanners the majority of studies have reported either unchanged [ 24, 25] or increased [F]FDG [ 26– 28] uptake in transgenic models.
Concurrently, some prototypes of an MR-PET scanner for simultaneous human brain studies have been built, their performance is being tested and preliminary applications have already been shown.
Doses can be expected to differ on the basis of protocol design and the type of CT scanner used, but only few studies have tried to estimate the real dose level of CT examinations performed daily in radiological centres [8, 9, 10, 11].
A conventional PET scanner is so large that these studies have to be performed with the subject lying inside a large tube.
Other studies have shown that modern CT scanners have a sensitivity of 90-100%, a specificity of 91-99%, and a positive predictive value of 95-97%.
Other studies have directly sampled participants' ongoing conscious experience in the scanner [16], [41].
Almost all of these studies have been exclusively carried out with dedicated animal scanners using either external or implanted coils.
Most of these studies have been carried out at the rather widely available 1.5 T clinical scanners [14], [15], [16].
10, 22 No studies have been found to report inter-observer variability for measurement of MAE using pocket-sized scanners, only high-end scanners operated by experts.
To date, many studies have been published assessing the diagnostic performance of CT coronary angiography with different generations of scanners.
