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In order to observe the count-rate response of the scanner at high activities, a decaying phantom experiment was performed.
We aim to investigate the performance of a PET-MR scanner at high count rates encountered during MPI studies using a decaying-source experiment to examine count-rate effects on quantitative accuracy, and also to investigate count-rate effects on quantification of perfusion values using a cardiac perfusion phantom to experimentally simulate clinical MPI studies.
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HistoGreen/NFR-stained sections were scanned with the Minolta Dimage Scan Elite 5400 slide scanner at highest resolution (5400 dpi, corresponding to approximately 5 µm per pixel) in the colour positive mode, for which purpose the slide scanning rack had been adapted to hold 3 standard microscope slides.
Detection of scanners at high-speed links requires a high-speed memory and such memory devices are expensive and limited in size.
Nevertheless, other factors such as scanner counting performance at high dead times, scatter corrections, and accuracy of the injected dose remain that might play a role and could be investigated further.
A very real challenge to these studies is the noise created by the MR scanner itself, particularly at high field strengths, and when using scanning sequences optimized to provide higher signal to noise ratios [ 12].
While rigid AFM scanners are operational at high speeds with the drawback of reduced tracking range, multi-actuation schemes have shown potential for high-speed and large-range imaging.
By exploiting the possibility of some range scanners to acquire views at high frame rate (e.g. Kinect and alike sensors), hand-held on-the-fly acquisition and alignment solutions have been proposed [25, 26] with specific solutions for handling loop closure problems [27] or computational burden [28].
Slides were washed as recommended in the manufacturer's protocol and scanned on the Agilent Microarray Scanner with extended dynamic range (XDR) at high resolution (5 μm).
Open issues include the complementary use of dedicated breast-PET scanners in patients at high-risk for breast cancer, the relation between pathological characteristics of cancer diagnosed in BRCA carriers and 18F-fluorodeoxyglucose 18F-FDG -avidityy, and the predictive value of PET in patients at high-risk for ovarian cancer presenting with a pelvic mass or potential chemical markers.
The development of scanners that operate at higher magnetic field strengths will also increase the sensitivity of MRI/MRS.
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