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The authors of [28] propose a hybrid scaling technique that utilizes reactive rules for scaling up (based on CPU usage) and a regression-based approach for scaling down.
The data followed a one to one correlation when using εavg (Fig. 7A), but when scaling up based on constant vtip (Fig. 7B) a global best fit was achieved when the STR was operated at twice the USD impeller tip speed.
The labelling method arrived at after scaling up based on these optimisations, and subsequently used for in vitro and in vivo biological evaluation, was as follows: neutralised gallium-68-generator eluate prepared as described above (300 μl, 60 90 MBq) was added to THP-mal-J591c-scFv solution (80 μg, 200 μl).
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The culture of M. alpina was scaled up based on the results of the flask culture.
Next, this cost-saving estimate was scaled up based on the actual number (43,931) of older adult patients presenting at, and discharged from Massachusetts EDs for all fall-related injuries in 2012.
As to pricing, Co-Founder & CMO Richard Mendis says that the startup's pricing begins between $15K and $20K per year, and scales up based on usage from there.
A look at the future of scale-up based on the use of such tools is presented.
A new correlation that is a combination of Zwietering and Baldi, and is robust in scale-up based on constant power/mass is proposed.
It is designed to be used by LCA practitioners with limited knowledge in the field of chemistry or chemical engineering and help to perform such a scale-up based on a logical and systematic procedure.
The process model has the potential to predict local temperature and shear conditions within an ice cream freezer and therefore represents an important first step towards systematic freezer design and performance optimisation and scale-up based on product quality considerations.
It is demonstrated, however, that scale-up based on the mixing length distribution is possible when it is obtained from a consistent set of data for liquid velocity and gas void fraction profiles.
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