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The principal components (PCs) are eigenvectors generated from either the covariance matrix (scaled sum of squares and cross products) or the correlation matrix (sums of squares and cross products from standardized data) of the variables involved.
In all cases, the fit of the values predicted by the model to the experimental data was estimated on the basis of the parameter σ, corresponding to the scaled sum of square differences between predicted and experimental values.
Hydrogen production is modeled as dependent on the scaled sum of electrons coming from endogenous substrate catabolism (the PSII-independent pathway, dependent on p) and from the residual level of the PSII activity (the PSII-dependent pathway, dependent on s) (Fouchard et al., 2005; Happe et al., 2002).
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Small β tends toward L 1 norm and large β tends like a scaled sum-of-squares measure, so different β will produce different inversion results.
The relationship of regional cortical thinning to severity of symptoms was also investigated by correlational analysis between ROI thickness and the Clinical Dementia Rating scale Sum-of-Boxes (Morris et al. 1997), a measure of severity of cognitive and functional impairments in daily life.
Finally, a recent FDA draft guidance suggested that the composite Clinical Dementia Rating scale Sum-of-Boxes score be used as the primary outcome measure in pivotal clinical trials involving individuals with mild cognitive impairment due to AD or prodromal AD [ 31, 32].
We used longitudinal Clinical Dementia Rating Scale Sum of Boxes data, retention rates, and the proportions of trial-eligible cognitively normal participants age 65 and older in the National Alzheimer's Coordinating Center Uniform Data Set to model trial sample sizes, the numbers needed to enroll to account for drop out, and the numbers needed to screen to successfully complete enrollment.
It is important to note that cVC itself is not a mean or a sum, but a fine scale sum of means.
To assess global performance we use the Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) [ 9, 10].
The Clinical Dementia Rating scale Sum of Boxes (CDR-SB) was a secondary outcome measure in each trial.
ADAS-cog: Alzheimer Disease Assessment Scale - cognitive subscale; aMCI: amnestic mild cognitive impairment; CDR-sb: Clinical Dementia Rating scale sum of boxes; SD: standard deviation.
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