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We simulated using a four-allele model, where each simulation included a neutral site and a linked selected site at which the scaled selection coefficient was σ = 2 N e s for the selectively-favored allele and σ =0 for the remaining three alleles.
Each simulation included a neutral site and a linked selected site at which the scaled selection coefficients for the four nucleotides were σT = 0, σC = 2Nes, σG = 2×2Nes, and σA = 3×2Nes.
And γ j = 2 N r e f s i is the scaled selection, in which s i is the relative selective advantage of variants in population i.
The scaled selection coefficient that most closely reproduced the observed skew was estimated to be 2.1 by linear interpolation between 2Nes equal to 2.0 and 2.2.
We used the ancestral selection graph to estimate the scaled selection coefficient that would give rise to the observed skew towards rare derived alleles at regulatory polymorphisms.
We estimated a scaled selection coefficient of ≈2 for typical cis-regulatory changes, indicating that selection, though detectable, is rather weak with stochastic forces playing a significant role in shaping patterns of within population cis-regulatory diversity.
Similar(43)
This paper designs a Markov random field (MRF) scale selection model, which selects scales for image segments, then the denoised image is the composition of segments at their optimal scales in the scale space.
The resulting technology provides efficient, large-scale selection of exquisite protein-binding reagents selected specifically for use in highly-multiplexed proteomics arrays.
You have to address the same issues of scale, selection, composition, proportion, and harmony when you're making a graph as you do when you're painting a picture.
Experiments show that the performance of MRF scale selection model is much better than the previous global scale selection schemes.
This experiment was conducted without applying our automatic scale selection algorithm.
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