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*Demographic parameters were scaled assuming a mtDNA mutation rate of 1.64 x 10−7 [ 89 ].
Demographic parameters were scaled assuming a generation time of 20 years for chimpanzees [ 90 ].
The output was scaled assuming a doubling time of 0.67 years per generation and a mutation rate of 2.5 × 10−8.
The space group was assigned as higher symmetry C2/ c. Processing of the in-house data for (3) was problematic, which was likely complicated by the long c axis, and only triclinic P1 appeared to be the most reasonable space-group choice with the R sym for P21 being 0.167 even when the data were indexed, integrated and scaled assuming a P21 space group.
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These parameters were scaled assuming an mtDNA mutation rate of 1.64 x 10 – 7 [ 89], an intermediate microsatellite mutation rate of 7.75 x 10 - 5 [ 87], and 20-year generation time [ 90].
After identifying the SNR data that were strongly affected by multipath, the data were converted from dB-Hz in logarithmic scale to watt per watt in linear scale, assuming a 1-Hz bandwith.
This sample size provides a 90% probability of detecting a difference between group means of 10 points on the Lower Extremity Functional Scale, assuming a standard deviation of 12 based on a recently published study [ 41].
With 30 subjects planned in each arm, a two-sided 95% CI for each group mean response had a half-width of 0.36% on the A1C scale, assuming a standard deviation of 1.00%.
Sample size was defined in order to detect a 2-point difference between groups on the pain intensity outcome measured by the Pain Numerical Rating Scale, assuming a standard deviation of 1.9 points [ 24].
(C ) The transcript causality p value scores (y -axis) are shown for each module transcript (log scale), assuming a representative variant in the module's genomic interval (rs13475891 in chr1 62 Mbp).
A sample of 76 participants (38 per group) would provide an 80% probability of detecting a difference between the group means of 10 points on the 80-point Lower Extremity Functional Scale (assuming a SD of 15 points, based on data from our recently completed trials [ 5, 6]).
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