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Culture and process optimization strategies and culture oxygen demand reduction are discussed, along with basic bioreactor scale-up principles and aeration process economics.
A section in this chapter discusses the challenges associated with scale-up of the high-shear wet granulation process, the various scale-up principles that are commonly used, and their broad classification into attribute-based and process parameter-based approaches.
The model was used to test different scale-up principles by comparing simulation results with experimental temperature and humidity data obtained from inorganic salt coating of placebo cores in three pilot fluid bed scales being a 0.5 kg small-scale (GEA Aeromatic-Fielder Strea-1), 4 kg medium-scale (GEA Niro MP-1) and 24 kg large-scale (GEA MP-2/3).
For biogas plants, as an example of the importance of efficient mixing, the scale-up principles 'geometric similarity'constantant impeller tip speed'similarlar viscosity and flow characteristics' as well as 'scale-up of particles and fibers of the dispersed phase' are proved to be valid by the Fraunhofer Institute for Ceramic Technologies and Systems IKTSS).
The scale-up principle is one of maintaining the same geometric ratios as laboratory scale devices, and ensuring similar values for the oscillatory and net flow Reynolds numbers.
The contextualization of the CSC process and results is a critical factor for scale up, as illustrated in the principles of implementation science, and will require further consideration and empirical research for policy integration [ 31, 32], [33].
Scale up procedures, derived from the application of first principles, cannot be applied if intrinsic reaction kinetic data are not available.
The same design principle is successfully used for easy scale up of the reactor capacity from 250 L/h to 10,000 L/h.
Biotech Scale Up: People.
Time to Scale Up.
Scale — Up (Additional components).
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