In-house pilot-plant facilities allow scale-up of processes and products for fast commercial development--something, Evans says, that is more problematic in European academe.
The opportunities to generate release particles from small molecule therapeutics to biologic drugs and nucleic acids, the scale-up of processes and perspectives are examined.
Therefore, increasing productivity during scale-up of processes has largely depended on trial-and-error screening, somewhat refined by the adoption of the multifactorial design of experiments (Zhao et al. 2008; Holmes et al. 2009; Jafari et al. 2011).
Mathematical models that accurately predict biochemical phenomena provide the basis for design, control, optimization and scale-up of process systems (Huang and Wang 2010).
Additionally, reasonably accurate mathematical models able to predict biochemical phenomena as well as the determination of its parameters are essential since they provide the basis for design, control, optimization and scale-up of process systems (Huang and Wang 2010).
Process scale-up of microencapsulation processes combines science, engineering, and experiential learning.
The scale-up of chemical processes is not such a trivial process and requires a certain understanding of the involved steps.
A versatile method for design and scale-up of CLR processes, starting either from model-based optimisation or from empirically developed processes, is proposed in this paper.
One of the main pending tasks is the development of a systematic procedure for the design and scale-up of these processes.
Problems occur during scale-up of these processes, where heat transfer becomes the limiting effect.
The challenge for scale-up of catalytic processes is illustrated with examples from steam reforming and a few ppm reactions.
