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We concluded that the rubber plantation environment influenced Mastomys species' breeding and transmission of Lassa virus along spatial scale to humans.
Yes... applying a rating scale to humans.
Defining an optimal regimen experimentally is a daunting task and requires many years of "wet-lab" study in animal models, which must then be translated in scale to humans.
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This paper argues that the strict computational behaviorist position for the modeling of intelligence does not scale to human-like problems and performance.
These rodent models could be used in fetal/neonatal tissue dosimetry predictions to help design/interpret early life toxicity/pharmacokinetic studies with ATR and as a foundation for scaling to humans.
61, 66 The model was scaled to humans by accounting for system-specific differences while assuming drug potency to be the same across species.
Teeguarden et al. (2005) parameterized this rat model using in vivo data from rats after BPA exposure with subsequent scaling to humans.
Remarkably, apoB silencing with the new iNOP derivative required only 2.0 mg kg 1 siRNA, which is a therapeutically feasible dose when scaled to humans.
When tumor models are developed during preclinical evaluations, results can be scaled to humans, providing important information for rapid identification of the TI in humans, facilitating selection of dose regimens for testing during clinical development.
Quantitative PK and PK-PD data on unbound drug concentrations after IN versus IV administration obtained from animals provides the opportunity to create advanced mathematical PK and PK-PD models that can be scaled to humans.
Inside, the three-story space, with two balconies, is illuminated by three gigantic prismatic skylights embedded in the ceiling; neither banal nor grandiose, it is a perfect environment, scaled to human proportions, in which to browse.
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CEO of Professional Science Editing for Scientists @ prosciediting.com