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Field observations and field trips can be constrained because of distance, time, expense, scale, safety, or complexity of real-world environments.
Primary outcome was to evaluate the technique's efficacy, secondary outcomes the resolution of stress urinary incontinence, postoperative pain (VAS scale), safety and complications.
When taken weekly to prevent malaria, amodiaquine was associated with agranulocytosis and hepatitis [8], [9]; large scale safety data on AQ as a malaria treatment is lacking, but its safety is considered to be acceptable [10].
This makes the databases ideally suited to large scale safety studies of commonly used drugs.
Although cardiovascular events do not appear to be increased with intravitreal anti-vascular endothelial growth factor drugs, large scale safety studies are still needed.
A number of studies have not demonstrated significant efficacy, and there is a need for large scale safety studies to ensure that thromboembolic events do not become a major cause of morbidity.
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It is a phase-III trial, meaning the drug has already undergone small-scale safety tests in patients, as well as initial analysis of any side effects.
They usually are conducted concurrently with Phase 3 (large-scale safety and efficacy) clinical trials but may begin earlier if there is reason to suspect that the drug is a carcinogen.
The storms that routinely batter ships on the Bering Sea are legendary.A full-scale safety review is in the pipeline, but in the meantime a big oil terminal on the southern end of Russia's Sakhalin Island could open this year, resulting in a spike in eastward oil tanker travel along the route.
So Molyneux worked with an international team of researchers and the government of Zanzibar to launch the first large-scale safety study of all three drugs.
The paper describes the development and validation of a coupling methodology between the best-estimate system thermal-hydraulic code RELAP5-3D and the CFD code FLUENT, conceived for high fidelity plant-scale safety analyses of pool-type reactors.
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CEO of Professional Science Editing for Scientists @ prosciediting.com