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A continuous scale of regulation, tuning affinity, or context of a site that allows an increase in existing regulation is easier than evolving a functional site de novo.
Genes regulated by BDNF or MeCh in both CMP and control states were organized into coherent series (numbered 1 6) based on the polarity (up or down), magnitude of regulation and time scale of regulation (Figure 6A, B: Tables S15, S16, S17 (MeCh) and S18 S20 (BDNF)).
In these short time spans, the total amount of ferritin can be assumed to be constant, because the time scale of regulation is much slower.
Furthermore, the scale of regulation that can be achieved by these TFs is potentially limited by the metabolic burden imposed on the cells and the number of TFs that can be simultaneously encoded in a given cell.
Moreover, it is essential to determine the regulation of signaling pathways by miRNAs, since it will provide an understanding on the global scale of regulation by miRNAs, instead of looking only to individual targets [ 126].
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Across the United States, decentralizing scales of regulation, scientific uncertainty, and increasing citizen participation are creating new regulatory contexts.
This paper addresses the importance of attention to multiple scales in regulatory decisions, how those decisions should link together across scales of governance or decision-making, and how mismatches among scales of impact and scales of regulation can lead to regulatory gaps and breakdowns.
As a consequence, further research in the area would benefit from considering explicit links between the micro-scale of individual clinical decision-making and perceptions of evidence, the meso-scale of social contagion and marketing, and the macro-scale of regulation and competition.
However, as we are here interested in the long term behavior of the system, we do not take different time scales of regulation into account.
Thus the importance and scale of translational regulation and protein stability as means of gene expression regulation in T. brucei remain elusive.
The left answer corresponds to low (1 point), the middle to average (2 points) and the right to high autonomic regulation (3 points). 1) The autonomic regulation (aR) scale addresses the state of regulation of different autonomic functions.
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