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- The scale of biosynthesis required for axonal growth and thereby polarization, necessitates increased protein and membrane synthesis, in addition to the intracellular delivery of these building blocks to the growing axon tip.
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PAICS catalyzes steps 6 and 7 of purine biosynthesis required for proliferation of cancer cells.
Direction of metabolites to morphinan biosynthesis requires isomerization of (S)- to (R -reticuline.
Several steps of de novo sterol biosynthesis require molecular oxygen [ 3].
Some secondary metabolites are high value compounds, and typically their biosynthesis requires the involvement of cytochromes P450s.
Glycerolipid biosynthesis requires the assembly of fatty acids and glycerol.
Lewis antigen biosynthesis requires the action of three fucosyltransferases, FutA, FutB and FutC.
Starch biosynthesis requires the coordination of several enzymes, for which different isozymes have different functions.
Ribosome biosynthesis requires coordinated activity of three RNA polymerases, PolI, PolII and PolIII.
LC-PUFA and cholesterol biosynthesis require reducing power in the form of NADPH.
Prostaglandin biosynthesis requires AA release and PLA2G4A is essential for proper induction of PTGS2, an isoform of the PTGS synthetase in prostaglandin biosynthesis [ 32].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com