Sentence examples for scale mutation from inspiring English sources

In order to rule out the presence of observed mutation in normal population, an assay was utilized for large scale mutation detection using PCR-RFLP technique.

Large scale mutation detection is feasible using GBS as we have identified nearly five times larger number of genes than that of previous studies [ 23].

Recently, a large scale mutation screen in the coding region of FTO in 1,433 severely obese and 1,433 lean humans revealed novel mutations [ 120].

The rate at which the population evolves can be controlled by a scale (mutation) factor F, a user-defined positive real number from the interval [0, 2].

Transposable elements play an important role for genome organization and evolution as substantial providers of large scale mutation events, creating genetic variability that natural selection can act upon [ 1].

Thus an enormous amount of work, likely involving larger scale mutation screening efforts to gain more analytic precision, tests of segregation to examine penetrance and tumor spectrum, and perhaps development of functional assays to aid evaluation of rare missense substitutions, remains to be performed on with MRE11A, RAD50, and NBN.

During its attenuation, MVA acquired large genomic deletions totalling about 30 kb, resulting in the complete loss of 26 open reading frames (ORFs), together with truncation or fragmentation of a further 21 ORFs and numerous smaller scale mutations [5].

They are a major factor in genome evolution due to their ability to create large scale mutations and genome rearrangements.

Over the course of evolution, proteins undergo normal sequence mutations as well as large scale mutations involving domain duplication and/or domain shuffling.

So far, successful drug-specific predictive markers in NSCLC and in most malignancies include molecular phenotypes reflecting somatic genetic alterations; for example, small scale mutations or large scale structural gene changes.

It is interesting to note that all of these genomic rearrangements are already present in the primary tumor, suggesting that large scale mutations accumulate quickly in early oncogenesis of ovarian cancer.