Sentence examples for scaffold class from inspiring English sources

However, regardless of the potency of this specific compound, NSC11668 represents a new ScPma1p-inhibiting scaffold class that will prove useful in future drug-discovery projects.

This scaffold class included the 12 scaffolds that were previously identified as being X-linked in bears (Cahill et al. 2013).

The same scaffold class with inhibitory activity toward OCRL, INPP5B, Synaptojanin 1, INPP5E, and SHIP1 (Class II) also showed dose-dependent activity against INPP5A, while the Class I compounds did not inhibit INPP5A.

Based on our recent discovery of a new scaffold class by in vitro protein-based optimization, it was surprisingly found that YH239-EE (the ethyl ester prodrug of YH239) exhibits potent anti-AML activity in different cell lines and patient samples.

Although multiple scaffold classes have been reported to bind cross-β sheet structure, their mechanism of binding and their ability to interact selectively with aggregates of varying protein composition are not well understood.

Subsequently, compounds are classified into their matching scaffold classes by automated chemical sub-structure searches.

In order to improve inhibition activity, extend the structure-activity relationship, and validate selected initial hits as real hits, we performed virtual screening campaigns for these scaffold classes.

We identified eight major scaffold classes among the screen positives (see SI Figure 1).

The IC50 values for representatives from our lead scaffold classes are indicated in Table 1.

No representatives from the two main scaffold classes displayed significant inhibitory activity toward these enzymes, shown in Table 1.

This iterative optimization process quickly showed that members of only the first two scaffold classes, Class I and Class II, produced multiple hits with favorable qualities.