Although 58% of treated patients had SBP <140, 24% had poorly controlled HTN with SBP ≥150, indicating the need for improved treatment.
We noted only a small reduction in SBP (~5 mmHg) after unilateral injection.
SBP, HbA1c, and certain lipid values seem to be strictly monotonic predictors of survival.
Of 7,788 patients, 7,785 had baseline SBP data and 3,538 had SBP ≤120 mm Hg.
Main Outcome Measure: SBP 30 minutes after captopril administration at initial autonomic dysreflexia episode.
All-cause mortality occurred in 28% and 30% of matched patients with SBPs ≤120 and >120 mm Hg, respectively (hazard ratio 1.13 SBP ≤120 compared to >120 mm Hg, 95% confidence interval 0.86 to 1.49, p = 0.369).
Propensity scores for SBP ≤120 mm Hg, calculated for each of the 7,785 patients, were used to assemble a matched cohort of 3,738 patients with SBP ≤120 and >120 mm Hg who were well-balanced in 32 baseline characteristics.
HF hospitalization occurred in 38% and 32% of patients with SBPs ≤120 and >120 mm Hg, respectively (hazard ratio 1.33 SBP ≤120 was compared to >120 mm Hg, 95% confidence interval 1.04 to 1.69, p = 0.023).
Propensity scores for SBP >120 mm Hg, calculated for each patient, were used to assemble a matched cohort of 545 pairs of patients with SBPs ≤120 and >120 mm Hg who were balanced in 65 baseline characteristics.
Results: Orthostatic hypotension was present in 37 (52.1%) patients, of whom 13 had severe hypotension (standing SBP, [le]100mmHg).
When corrected for placebo, target SBP (<140 mm Hg) was reached in between 6% to 15% of patients on monotherapy.
