In addition, high-dose intermittent oral folic acid given in this study allowed administration of pemetrexed at the dose and schedule explored with a highly satisfactory safety profile and with no apparent compromise in efficacy.
Notably, this schedule has been recently proposed for systemic onset juvenile arthritis (SoJIA), so far with a satisfactory safety profile [ 21].
In this phase Ib/IIa clinical trial, MOR103 was well tolerated and associated with a satisfactory safety profile in patients with active moderate RA who received up to four doses at weekly intervals.
Emulsion systems used in dermopharmacy have to fulfill a number of requirements, for example, acceptable physical stability, chemical inertness, satisfactory safety profile, and an attractive appearance, and also provide an appropriate carrier system for the active agent.
Our study showed that, in a predominantly dengue-naïve population, three doses of CYD-TDV elicited a balanced, neutralizing antibody response against all four dengue serotypes and with a satisfactory safety profile compared with two licensed control vaccines.
The systemic safety of several iron oxide nanoparticles has been evaluated after injection in humans, indicating that these products have a satisfactory safety profile according to standard toxicological and pharmacological tests.
