The inferred signaling pathways had satisfactory recall and precision rates for most signaling pathways; for some, however, there is room for improvement.
We show that BowTieBuilder, given multiple source and/or target proteins, infers pathways with satisfactory recall and precision rates and detects the core proteins of each pathway.
This description was satisfactory inasmuch as the intricate pathways of metabolism and, later, the basic mechanisms of gene regulation and signal transduction were still being unraveled.
Back to step 2. Iterative development of pathways until a satisfactory range of plausibility with interest to transport demand futures is achieved. .
Controlling local concentrations of reactants, intermediates, and enzymes in synthetic pathways is critical for achieving satisfactory productivity of any desired products.
I left Nantes via the Erdre to get to the Nantes-Brest canal, and was soon trundling at a satisfactory pace along a wide and blissfully traffic-free pathway.
The synthesis of compounds D1 30 and F1 16 followed the general pathway as outlined in Scheme 1, gave satisfactory analytical and spectroscopic data, which were in full accordance with their depicted structures.
Finally, optimization leads to the identification of compound 19a, a potent Hh signaling pathway inhibitor with superior potency in vitro and satisfactory pharmacokinetic properties in vivo.
The agreement between measured and computed results is satisfactory, and the model was used to elucidate the oxidation pathways of DBE.
What really made an impact and turned the tables, I think, has been the growing power of popular and entertainment cultures to provide what Christianity no longer can -- meaning and fulfillment, pathways for transcendence and ideals to live up to, satisfactory explanations for death and a true, revelatory sense of personal identity.
However, insects lack several enzymes in the cholesterol biosynthesis pathway [ 1], which makes them auxotrophic for exogenous (dietary) cholesterol for satisfactory growth, development and reproduction [ 2- 4].
