Molecular dynamics (MD) simulations can provide atomically detailed views of protein motions, sampling multiple timescales ranging from femtoseconds to nanoseconds on typical computing resources.
We found similar results with additional functional variables (sample size = 22, Table S3), across a shorter evolutionary timescale (sample size = 128, Table S4).
31 Data that are collected for a research project can be tailored to the specific populations, timescales, sampling frame and outcomes of interest.
The CG model was expected primarily to sample the long timescale low frequency motions; differences in, for example, time steps (2 fs vs. 100 fs) between AA-MD and CG-BD imply that fluctuations would not be identical.
However, there is no evidence that subsequent pregnancy modified the effects of near miss with perinatal loss on social support, financial difficulties or K10 score to any large degree (results not shown), although the sample size and timescale of the study did not permit a thorough investigation of this.
Enhanced sampling methods allow this timescale to be effectively extended in order to probe biologically relevant conformational changes and chemical reactions.
Fish caught from the same location in different years were pooled for genetic analysis because the timescale of sampling was short in comparison with the 50-year life span of black rockfish.
This date was consistent with our clade-specific PCR amplification results; however, the timescale of sampling and rapidity of these outbreaks offer only limited variation across the core genome with which to infer evolutionary and epidemiological processes, and thus may impact the robustness of this analysis.
The small timescale and sample size of this study - together with the lack of a control group - make it hard to draw firm conclusions.
Heliocentric and planetocentric trajectory analysis has been conducted to assess the sail performance level required to return samples within a reasonable timescale, whilst maintaining manageable sail dimensions.
