Some drug penetration evaluation methods into the skin are mostly destructive; a representative sample of defined skin layer is isolated and, therefore, extracted for chemical analysis, such as: cryo-sectioning and tape stripping method (Brain et al. 2002).
The resultant supernatants were recovered, a sample of defined volume (5µl) was dried and weighed, and a defined amount of each sample was transferred to a clean glass vial either for further processing or for MRM-MS analysis.
Blood samples of defined volume (30 µl blood) were obtained before, 1 hour, 24 hours and 48 hours after R-848 injection or once/day at the indicated time points post IAV infection.
To evaluate the effectiveness of the proposed strategy, we first applied it to a sample of defined, exclusively eukaryotic composition.
When used in combination with vital dyes, this technique enables accurate enumeration of live cells within a sample of defined volume.
Control samples of defined methylation content such as those tested in this study may be a useful means of monitoring whole process precision.
The overall mesh porosity P was calculated according to P = (1 − ρ/ ρ0) × 100, where ρ denotes the density of the electrospun mesh and ρ0 is the bulk density of the electrospun mesh determined gravimetrically using weights of precisely cut samples of defined area and thickness; P was 75.2 ± 0.4%.
In a digital receiver a realization of a doubly dispersive channel can be represented by a sampled version of, defined by.
Extensive genomic profiling of tumour samples, particularly of defined subsets of patients who achieve extreme responses to antiangiogenic drugs, such as pazopanib, may allow for the identification of a landscape of novel druggable biomarkers.
A major advantage of testing samples for presence of defined resistance determinants is a better understanding of resistance spread, especially if resistance is conferred by mobile genetic elements.
