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Advantages of our study include the truly population-based design with strict sampling of control participants, the prospective and rapid case ascertainment with high participation frequencies, the personal interviews with all study participants, allowing robust exposure assessment, including all plausible confounding factors, and the prospective and thorough tumour classification.
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In nested case-control studies, sampling of controls is usually done by density of incidence and pairing.
Systematic sampling of cases (when necessary) and random sampling of controls will be implemented.
These results point to the need for concurrent sampling of controls with exposed populations.
Because we used risk set sampling of controls, the ORs provided unbiased estimates of incidence rate ratios.
The original Langholz and Borgan estimator assumed simple random sampling of controls from the set of known eligibles.
As this restriction was imposed after the sampling of controls, the final ratio of cases to controls deviated slightly from 1 8.
While areas of increased or decreased risk may theoretically be caused by non-uniform control selection, sampling of controls within the study area did not depend on geography.
As the latter restriction was imposed after sampling of controls, the final ratio of cases to controls deviated slightly from 1 : 8.
Some cohort members were selected as potential controls for more than one case, as it is in incidence-density sampling of controls within cohorts (Lubin and Gail 1984).
However, because population-based sampling of controls is not feasible in Iran, we had to rely on less optimal approaches for control selection.
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