The steepest gradient occurs between 5 and 15 MPa for all samples, with a progressive levelling off of the permeability change with confined pressure.
In this study a set of rat liver samples with a progressive loss in RNA quality was generated.
In this paper, we examined the effect of sample integrity on microarray performance through the use of samples with a progressive decrease in RNA quality that was indexed using a sensitive automated metric of RNA degradation (RIN).
To systematically explore how RNA quality affects microarray assay performance, a set of rat liver RNA samples with a progressive change in RNA integrity was generated by thawing frozen tissue or by ex vivo incubation of fresh tissue over a time course.
As expected, the number of core genes reduced dramatically with initial addition of strains in the random sampling, but stabilized with progressive sampling and reached a plateau.
We suggest that BPR can also be used to develop a prognostic gene signature for IPF by training a model with samples of rapidly progressive IPF versus slowly progressive IPF.
Eight samples were selected and named with progressive numbers, the volume reference and the acronym of the library (for instance 1_1869_BNM).
We finally probed bortezomib-sensitive, as well as bortezomib-resistant primary myeloma cell samples obtained from myeloma patients with progressive disease under bortezomib-containing therapy with the combination of bortezomib and nelfinavir.
DeGiorgio et al. showed that injection of anti-NR2 glutamate receptor binding antibodies (purified antibodies from the sera of SLE patients or one CSF sample from an SLE patient with progressive cognitive decline) into the mouse brain resulted in apoptosis of the neuronal cells without signs of inflammation [ 22].
"We were leaning toward progressive, cool samples with space and minimalism," Legend said.
