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Compared to CLART, HC2 tested positive in fewer samples with normal cytology, 16% (728/4,667), but in more samples with low-grade abnormal cytology, 64% (79/123) in ASCUS, and 90% (128/142) in LSIL.
The higher analytical sensitivity of PCR explains the higher detection rates compared to HC2 in samples with low-grade cytological and no histological abnormalities and may be suggestive of the presence of latent HPV infection requiring a molecular test with higher analytical sensitivity.
Participants 4201 women with low grade abnormalities.
Toxicity (all grades) occurred in 93.5% of participants, 50.9% with grade 3+ and 42.6% with low grade.
Patients with high grades of liver inflammation were older than those with low grade (Table 2).
Histological examination revealed tubulo-villous adenoma with low grade dysplasia.
This preliminary study had no patients with low grade DCIS.
PDZK1 expression correlated positively with low grade tumours (p = 0.010).
Expression of p21 was associated with low grade tumours.
Moreover, BMP4 was downregulated in high grade glioma when compared with low grade glioma.
Furthermore, better outcomes were found in patients with low grade of articular degeneration (Ahlbäck grade 1).
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