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As heterogeneous methylation can be identified but not quantified on MS-HRM analysis [ 100], two analyses were performed: one for samples with an estimated level of methylation 10% and greater while excluding samples with heterogeneous methylation, and the second analysis included all heterogeneously methylated samples in the same category.
The improved activity for CO oxidation over samples with heterogeneous Pt distribution is likely due to less tendency towards CO self-poisoning through the development of steeper concentration gradients in the Pt containing regions in the porous support material.
The properties of commercial samples with heterogeneous distribution of the substituents and laboratory-made samples, with a more homogeneous distribution, are compared to allow a better understanding of the thermogelation process of methylcelluloses.
To further asses the performance of PAC in samples with heterogeneous (wild-type and mutant) transcript expression, we performed PAC on 14 clinical glioblastoma specimens (selected to contain >70% tumor nuclei) that had genomic amplifications of the EGFR oncogene.
These samples included the 16/18 samples with heterogeneous methylation identified by MS-HRM.
Furthermore, in samples with heterogeneous staining for Tn, we observed a reverse correlation between ERK8 and Tn staining.
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When a sample with heterogeneous cell composition is probed with a nanoparticle (j), the total Δ(1/T2)j is approximated as the sum of the individual contributions by each cell type (i): Δ(1/T2)j = ∑ Rij·Ni.
We obtained only small numbers of samples with a heterogeneous mix of different tumour types.
The Nolla method showed greater predictive capacities than the Demirjian one in samples with more heterogeneous ages.
Although this approach produces a highly confident set of alternative events, it can result in a huge reduction of the dataset, particularly in case of comparisons across samples with highly heterogeneous gene expression levels.
Dot plots corresponding to Fp and Fr from a typical young donor (19 yr) (Fig. 4A and 4B, respectively), and from a typical older donor (74 yr) (Fig. 4C and 4D, respectively), indicated that all cell samples contained cells with heterogeneous morphologies.
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