Sentence examples for samples with functional from inspiring English sources

To confirm that the same is true of CLL cells, CLL samples with functional impairment of the p53 pathway were compared with samples that had no such dysfunction.

Samples with functional p53 showed significantly more retention of the p53 locus (genotype AB) as compared to the group with either aLOH (AAA/AAAA) (p=0.005), cnLOH (AA) (p<0.001) and cases with multiclonallity (p=0.006).

The database can store all SNP and indel calls from thousands of samples, along with functional annotation of the variants and, optionally, additional information about samples and sequencing runs.

69 70 The ability to analyse multiple gene sequences from large numbers of samples, complemented with functional screening and characterisation of randomly cloned DNA fragments from the GI tract, is currently being exploited to uncover changes in disease states including in inflammatory bowel disease (IBD).

GoNL will be an excellent starting point to enrich the GWAS samples with more functional DNA variation, and with the BBMRI-NL infrastructure there is an excellent basis to further explain the functional consequences of disease-associated variants.

Samples with different functional characteristics were prepared partially substituting sucrose by bulk sweeteners.

We develop and apply an iterative sampling scheme to generate non-disease samples with a functional composition similar to that of the disease sets.

This demonstrates that the OD method can, in addition to finding the divergently expressed genes for a single sample, identify and prioritize those genes with shared dysregulation between samples with similar functional or clinical phenotypes.

In conclusion, the newly designed ATM-p53 RT-MLPA assay is able to distinguish three subgroups of CLL tumors (i.e., TP53-defective, ATM-defective and WT) and was also able to detect additional samples with a functional defective DDR, without molecular defects of TP53 and/or ATM.

These novel alleles may indicate adaptation to the pathogen community found in captivity (Fig.  1), although further sampling along with functional testing is needed for verification.

That said, subtle changes in electrode placement that may be hard to discern in small samples are correlated with functional differences between MFB self-stimulation sites [78].