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First, we can decide in advance how many samples will be needed to achieve a given level of confidence.
These methods may provide insight into axonal architecture in normal and abnormal WM tissue but additional validation with more samples will be needed.
Additional studies with well-documented patient samples will be needed to address this question.
Sample limitation was also an impediment to do further functional analyses related to the proteins identified; more samples will be needed to do so.
In addition, the pooled estimates of association suggest that the new data is consistent with the original findings: larger samples will be needed to provide accurate estimates of BPA associations with diabetes or liver enzymes to exclude the possibility of real associations being present.
Replication studies with larger samples will be needed.
Similar(26)
However, single voxel proton MR spectroscopy, although limited by the volume sampling, will be needed in clinical trials and longitudinal studies to further increase accuracy.
A further prospective study with a large sample will be needed to confirm these.
Validation of our concept with a clinical sample will be needed in future studies.
Much further gene and taxon sampling will be needed, however, to strongly resolve individual deeper nodes.
By design, G × G × E interactions require large sample sizes, so that independent replication and extension in a larger sample will be needed to confirm our finding.
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