Cereulide was not detected in any of the collected samples, which supports the theory that contamination most likely occurs due to improper storage and unhygienic conditions.
Furthermore, post-circumcision samples formed a smaller cluster than pre-circumcision samples, which supported our earlier observation of the decrease in microbiota heterogeneity after circumcision.
Importantly and whatever the method used to quantify HMGB1, a positive correlation was observed between HSV2 replication and HMGB1 concentrations in these samples, which supports the involvement of HSV-2 in HMGB1 release through virus-mediated cell necrosis.
Our qPCR validation shows downregulation in all squamous cell carcinoma and adenocarcinoma samples, which supports the previous findings and RBL1's function in tumors.
Somatic mutation analyses of the immunoglobulin heavy gene locus by ultra-deep sequencing in chronic lymphocytic leukaemia detected multiple subclones in most samples, which supports this model (Campbell et al, 2008).
The irradiated sample leached about 14 times as much Cu compared to the dark sample, which supports the hypothesis of photooxidation promoted Cu+ release (Section S3.5).
We had only 5 cases (2%) reported to ESPED which could not be matched definitely to cases in the random sample, which supports the assumption that the review procedure is able to detect very close to 100% of all existing cases of IS.
The plasma protein levels of osteopontin increased from 250 ± 60 ng/mL in controls to 390 ± 100 ng/mL in post-MI samples, which adds support for the critical role of macrophages in our mathematical model.
Another important future direction to extend MixClone is to implement joint analysis based on multiple samples, which is supported by PyClone and PhyloSub [ 5, 7].
In most samples, CXCL9 protein was also expressed by endothelial cells (15 of 20 samples, Figure 1f) and was found in the extracellular matrix (ECM, 17 of 20 samples), which is supporting data by others showing that CXCR3 ligands may bind to the ECM [ 27].
