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Using primer-shift PCR analysis of human tissue samples we demonstrated that following ischemia there is a large mitochondrial DNA (mtDNA) deletion (approximately 7.3 kb) that encompasses the region encoding 11 electron transport protein subunits [13].
Using a group of well-characterized samples, we demonstrated that CNVplex® was an efficient, highly reliable method with high sensitivity and specificity.
Using an exceptional panel of human thymic samples, we demonstrated that medullary thymus epithelial cells (mTECs) promote the generation of tTreg cells and favor their function.
Because their expression profiles and genetic backgrounds were thought to vary across the samples, we demonstrated several approaches to integrating individual assemblies derived from all of the samples (Fig. 4).
With another enzymatic assay on various samples, we demonstrated that considerable amounts of 5-hmC were detected only in skeletal muscle tissue at three tested CpG sites in upstream, intronic, or 3′-terminal clusters of CpGs exhibiting MbMt hypermethylation.
By analysis of 28 DCIS patient samples, we demonstrated that DCIS lesions expressing higher nuclear BCL9 (percentage of cells expressing nuclear BCL9) were more likely to be ER-negative, PR-negative, high nuclear grade, and high in HER2 expression.
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Using spiked samples, we demonstrate that this discrepancy is due to the association of LAM with high-density lipoprotein (HDL) nanodiscs in human serum.
By comparing the complete set of endogenous metabolites in the human metabolome database to actual plasma, urine and stool samples, we demonstrate that up to 28.5%% of detected features are likely salt clusters.
Through the chemical and mineralogical analysis of slag samples, we demonstrate the existence of an extensive copper-production industry and reconstruct several key aspects of the smelting technology during the Late Bronze Age and Early Iron Age.
Using NSCLA cell lines and primary patient samples, we demonstrate that the SP, CD133pos and ALDHhigh cells are phenotypically distinct subpopulations enriched for CS/PC activity.
In our current analysis of colon and lung cancer samples, we demonstrate that Mcl-1 and Bcl-xL are overexpressed and also co-exist in many tumors and that the expression levels of both genes correlate with the clinical staging.
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