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A candidate gene approach is a valuable alternative, as it needs only a few hundred samples to highlight even modest genotype-risk associations, with the caveats that it requires some knowledge of disease pathophysiology, knowledge that may be biased.
Dr Hansen gave an overview of the currently available functions for QC, normalization, and also mentioned functions that would be released in the near future for predicting the sex of samples to highlight mislabeled samples, a function to estimate cell composition and a DMR caller.
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Figure 4 displays a schematic representation of identified peptides from the haptoglobin protein in the three OvCa samples, shaded to highlight identified peptide sequences along the length of the entire protein.
Both plasma and joint (synovial) fluid were therefore analyzed, and results were compared between duplicate spots within individual arrays, within the same sample type across different patients, and between sample types to highlight potential correlations and differences in autoantibody levels.
In the sections to follow, we present three additional sample assemblies to highlight the ability of PRICE to address particular assembly challenges commonly encountered in real-world datasets.
The case examples presented in this paper were purposefully selected to exemplify the diversity of the sample, and to highlight specific issues related to subjective experiences of health.
Data verification was performed by comparing the average, standard deviation and quantiles of each sample, in order to highlight the samples which present excessively different contributions.
The sample design for a major health survey, the Third National Health and Nutrition Examination Survey NHANESS III), is used to illustrate a complex, multistage probability sample design and to highlight some of the sampling issues discussed in this article.
Those samples were used to highlight the effect of applying a small data set to network analysis.
Alternatively, the reduced number of haemolysis-free samples was insufficient to highlight differences between cases and controls.
In the proposed system, microscopic images of blood smear sample are processed to highlight the WBC for segmentation.
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