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Although our study is of limited sample size, we would generally expect small samples to contribute to a high type 1 error rate.
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As samples are allowed to contribute to a particular module only to a certain degree, decomposition methods can detect local co-expression.
If reliabilities of observed samples differ from sample to sample, each sample can contribute to the maximum likelihood estimate in proportion to its reliability through WLL.
Usually, high methylation variance across samples may contribute to heterogeneity specific to diseases33.
The largest family contributes 14 samples to this study; 16 families contribute a single individual.
In biclustering, samples either contribute to a particular module or not, in contrast to decomposition methods where all samples contribute to a certain extent.
These fractions of samples they contribute to are then averaged over all trees and used to rank the features.
The third approach adaptively assigns weights to the nodes based on how the rest of the samples contribute to the sparse representation of the nodes.
The relative ease of collection of urine samples compared with blood samples contributes to this choice.
All sequences are deposited immediately they are completed, as agreed by all the centres contributing samples to this project.
Thanks to the patients who contributed samples to this research.
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