IVIVCs should utilize sufficient subjects (a statistically powered sample) to adequately characterize the drug product performance.
Similarly, we do not attempt to fix these genus-level problems here, as most will require more extensive taxon (and potentially character) sampling to adequately resolve.
Our results support the use of a single serum sample to adequately represent a more biologically relevant dose (concentrations in follicular fluid), as well as exposure levels over time, in epidemiological studies of ART outcomes in relation to organochlorine exposure.
The t½ parameter could not be determined, because there were insufficient CSF and plasma samples to characterise adequately the switch from the first to the terminal exponential phase.
It is known that resting state functional connectivity studies benefit from higher sampling rates to adequately sample undesirable respiration and cardiac effects [42], while for event-related task fMRI, faster sampling could allow for a better characterization of the hemodynamic response.
This finding may have resulted from sample pretreatment to adequately purify DNA (26 ).
Critical to this is the establishment of accurate sampling frameworks to adequately capture the presence and amplitude of the molecular events (often short-lived) that underlie immunological responses.
Moreover, none of the previous studies have had a sufficient clinically rich population-based sample size to adequately address these relevant questions.
Recruiting difficulties can lead to: responder bias, an insufficient sample size to adequately power statistical analyses for hypothesis testing, costly delays in achieving the research objectives, and as a worst case, early cessation of the research project.
