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A similar developmental delay has been reported in humans; as serum TCDD concentrations increase in either prenatal or premenarcheal samples, the timing of pubertal breast development is delayed (Den Hond et al. 2002; Leijs et al. 2008).
9, 10 These include differences in the biological material used to measure the lead level, the timing of the samples, the range of lead levels in the samples, the timing of any specific lead exposure, and substantial differences in the methods used for statistical analysis, including choice of confounders, under- and over-control of confounders, and the use of categorical or continuous data.
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In general, it is difficult to explain the actual discrepancies in the prevalence of Cryptosporidium spp. and G. duodenalis among different studies because the infection rates are related to many factors, including the examination methods, age distributions of the animals, sample sizes, host health status at the time of sampling, the timing of specimen collection, and geo-ecological conditions.
Table 1 outlines the test antibiotics (antibacterials and antifungals) to be sampled, the timing of pharmacokinetic sampling and the pharmacodynamics endpoints that will be tested for each antibiotic and dosing regimen.
In the case of linear k-space sampling, the timing of k-space center data acquisition was unlikely to coincide with actual peak CA concentration for all patients, and thus, measured Emax was expected to be lower than Ecalc in most cases.
Another limitation of this study is that we were unable to adjust for the distribution of peripheral blood leukocyte populations in our whole blood samples or the timing of the blood sample collection from the umbilical cord.
Decisions related to study design include sample selection, the timing of symptom measures, and the characteristics of symptom interventions.
These data are collected systematically throughout the year and are an unbiased sample of the timing of influenza activity.
However this could be due to the small sample size, the timing of the study and a nondiscriminatory protocol.
For the IPR estimates reported here, we have matched to the extent possible the timing of urinary excretion sampling with the timing of production data.
Each of these stochastic mappings results in a fully geographically annotated tree sample, including the timing of migration events within branches.
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