Sentence examples for samples the challenge of from inspiring English sources

To fully exploit these clinical samples the challenge of isolating adequate RNA yield directly and generating sufficient microarray probes for global transcriptional profiling from this low level RNA input has been addressed in the current report.

Moreover, because it uses the same small-molecule affinity matrix in both the control and experiment samples, it circumvents the challenge of selecting an appropriate control matrix.

Similarly, genetic screens of patient tumor samples have highlighted the challenge of tumor heterogeneity in both personalized medicine and biomarker development, finding intratumor mutational disparities in renal cell carcinoma patient biopsies 111.

We explain the major technical challenges that have caused difficulty with predicting novel ligands, including the problems of sampling noise and the challenge of using benchmark datasets that are sufficiently unbiased that they allow the model to extrapolate to new regimes.

Recent whole-genome sequencing of cohorts of hundreds of patient samples illustrates the challenges of identifying driver mutations outside the exome46,47.

In neonates, however, two major difficulties arise when taking blood samples for coagulation tests: the challenge of venous access and the comparatively large amount of blood required.

While PUs provide rapid assessment of diversity within a sample, they do not address the challenge of upscaling from samples to estimate total species diversity in an area.

Or worst of all, the lone drunkard, pink of cheek and musty of odour; a casualty of a delayed flight with nothing to pass the time besides the challenge of sampling every beer in Wetherspoons, and who will without fail fall asleep on your shoulder and dribble.

Our study included a small sample of participants, which reflects the challenge of studying a classroom environment in residency.

As an alternative a direct α-85 B immunoblot assay was developed to avoid the challenge of sample pretreatment in sandwich detection.

Barriers include the need for longitudinal studies that cover relevant developmental stages and for samples large enough to deal with the challenge of testing gene-environment-development interaction.