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16 Classical approaches require twin and family samples, the availability of which is limited by the substantial difficulties and high costs inherent in their recruitment.
As they discussed, some important limitations of their studies have to be noted: retrospective study, selection bias of samples, the availability of suitable tissue and absence of a set of nonmalignant control samples, all affected miRNA expression differences.
When designing PK PD studies in paediatrics certain factors need to be taken into account, e.g. the age range of the paediatric group, the therapeutic index, the possibility of collecting blood samples, the availability of validated PD endpoints for children and the availability of sensitive analytical methods.
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Strengths of this study include a randomly selected general population sample, the availability of HIV and HSV-2 test results linked to responses to a structured interview, and a relatively large sample size.
The following criteria were used for our taxon sampling: the availability of cultures and ease of cultivation, the presence of a sizable research community, the history of research with this organism, the perceived potential for development of advanced molecular tools, and their key evolutionary positions in two major charophyte orders.
This practice may be avoided because brain tissues contain much higher amount of these compounds than CSF samples, but it might be followed for CSF samples because the availability of CSF samples is usually very limited.
Finally, a great advantage of zebrafish bioassays in EDA of environmental samples is the availability of mechanism- and endpoint-specific methods for the identification of important classes of contaminants.
It is a noninvasive method for the detection of biomarkers rather than directly encountering the patient samples, and the availability of so many cell lines that represent the different stages of the disease helps to provide relevant information [ 104].
Methodological strengths of the present study include the large sample size, the availability of comparable survey instruments, the sampling strategies and methods of data collection, and also, the diverse nature of the various oral health-related behaviors.
Therefore, there is an interest in using whole genome amplified (WGA) DNA samples created from patient samples instead of native DNA samples to increase the availability of appropriate samples to query the performance of the assays.
They found that kaolin (commercial sample) reduced the availability of two types of tannins and quinine (another plant secondary compound).
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