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To some extent, these observations appear to extend to biofluids such as blood plasma or (especially) serum; SERS spectra of such biological samples often exhibit a low signal-to-noise ratio in the absence of nanoparticles.
Finally, for each SNP, low peak height genotypes (<25% of the average peak height) were removed; we apply this procedure because poor quality samples often exhibit high background noise that SNPlex can mistake as heterozygotes.
Finally, for each SNP, individual genotypes were omitted if their peak heights were <25% of the average peak height for that genotypic group as measured across the entire sample; we apply this procedure because poor quality samples often exhibit high background noise that SNPlex can mistake as heterozygotes.
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Moreover, heterogeneous samples often display variable composition.
About one-third to one-half of shark attacks worldwide are attributed to great whites, but research indicates that great whites often exhibit "sample biting" and then release their victims; they don't necessarily prey on humans.
These targets can be guided by prior experience (for example, cancer datasets often exhibit substantial sample heterogeneity) or by the use of technical and biological replicates.
Sample profiles too, such as cell or disease types, often exhibit characteristic expression profiles [ 2].
Additionally, the sample size in this study is very small, and BxD lines often exhibit non-local linkage disequilibrium due to limited recombination across few individuals.
Several hyper- and hypo-methylated genes in BPA-high compared to BPA-low samples corresponded with expression change, adhering to the general agreement that methylation and expression often exhibit inverse directionality.
Chronic alcoholics often exhibit psychotic symptoms.
Instead they too often exhibit knee-jerk defensiveness.
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CEO of Professional Science Editing for Scientists @ prosciediting.com