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In the stool samples of autoimmune Turku children, levels of B. dorei peak at about 7 months of age, about 1 month prior to the Finnish national standard for the timeframe of solid food introduction [ 15].
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Interestingly, circulating proteasomes were found in serum samples of patients with autoimmune myositis, SLE, primary SS, RA, and autoimmune hepatitis [ 17- 19].
The weaknesses of our study includes a clinical sample with an assessment of autoimmune disease that is documented only by medical history which can be influenced by poor recall, small numbers of study subjects and the lack of documentation of specific antibodies that may affect the offspring.
Compared with this study, longer-term follow up research should look for yet unknown potential side-effects related to high-dose vitamin D3 treatment of a larger sample of subjects with autoimmune disorders.
Our patient cohort data support and expand on a previous report showing higher serum levels of BLyS/APRIL heterotrimers in a limited sample of patients with autoimmune diseases (n = 15) compared with healthy controls (n = 6) [ 6].
The control sample consisted of 553 NZ European Caucasians (226/552 male; 40.9%) with no history of autoimmune disease.
The controls' samples were clinically assessed to be without SLE, other autoimmune disorders, systemic disorders or family history of autoimmune disorders (including first-, second- and third-degree relatives).
(Three-quarters of autoimmune patients are women).
Have you ever heard of autoimmune diseases?
A common symptom of autoimmune diseases is debilitating fatigue.
B cells have important functions in the pathogenesis of autoimmune diseases, including autoimmune rheumatic diseases.
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