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Although the optimum number of samples may differ by region of the country or in different neighborhoods within communities, depending on the pollutants of interest and geographic and temporal variation in the processes driving air pollution, this general strategy may be of use in planning efficient National Children's Study substudies.
Note that since the national annual income distributions were based on data from the full national samples (only excluding those respondents with zero or missing incomes), the proportions falling in the lower and upper quartiles for the analytical samples may differ substantially from 0.25.
First of all, handling of blood and tissue samples may differ considerably between laboratories.
It is recognised that study samples may differ from the target population.
In these cases, the experimental DNA samples may differ to a large extent between treatment and control groups, warranting application of normalization to each condition separately.
Even when profiling replicates, the distinct number of miRNAs identified in replicate samples may differ because of the random sampling nature of the technology; normalizing to the library size ignores this.
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A limitation of repeated samples is that each sample may differ in important ways that are unmeasured.
The participant sample may differ from smaller-sized practices or FQHCs who do not adopt electronic data exchanges and our findings may not generalizable to these settings.
All participants were recruited from patient education courses, and thus, this sample may differ from the broader population of persons with morbid obesity.
Furthermore, the overall patterns of general self-efficacy in this sample may differ from those of persons who are not attending such courses.
Our sample may differ from the target population of older adults with back pain given the unique geographic setting of our study.
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