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An example for this is the pathway enrichment analysis query (see Additional file 2, lower panel), which for all KEGG pathways determines whether the number of mutated genes found in a subset of samples is statistically significant.
While pooling RNA samples from within populations of interest to form a set of pooled samples is statistically valid and efficient when comparing among populations [ 14], pooling a small amount of each sample of interest to form a reference sample is still subject to the first and second disadvantages of the strategy depicted in Figure 1A.
If a genetic variation on a locus with the disease samples is statistically significant to the controls, the SNP is considered associated with the disease, whereas expression Quantitative Trait Loci (eQTL) studies have been actively done to identify genetic loci that regulate gene expression [ 3].
To determine if the differential expression for drug targets or disease genes between case samples and control samples is statistically significant, we calculated P values for drug targets and disease genes by comparing each to the distribution of differential expression values for all genes.
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Statistical analysis revealed that the particle-size distributions between the survey samples were statistically identical, suggesting no overall difference in main-channel-bed sediment-size distribution between 1925 and present.
For data sampling, the age-old mantra has been to ensure that samples are statistically representative of the future cases that a given model is likely to encounter.
Results obtained for commercial samples were statistically comparable with those obtained by an HPLC-reference method.
The differences with the untreated Hha samples are statistically significant according to a Student t-test with P=0.03 (for sulfonic acid) and P=0.02 (reduced and other oxidized forms).
The characteristics of acoustic emission events produced during torsional deformation of bulk metallic glass samples were statistically analyzed.
The performance of the trained classifier on unknown samples depends on the quality (whether the training samples are statistically representative of the patient population) and the quantity (sample size) of the training samples.
Hydrochemical results of all samples were statistically analyzed by the software STATISTICA® (1998).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com