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Histopathological analysis of tissue samples is frequently used (Spangehl et al. 1999, Bauer et al. 2006).
The concentration of pathogen DNA in biological samples is frequently very low, close to the detection limit.
Va, isolated from Sepia officinalis and Trachurus trachurus samples, is frequently detected from fin fish, shellfish, seawater, and sediment [ 7].
Availability of appropriate and clinically well-documented samples is frequently a major bottleneck for biomarker studies, even if all other aforementioned gaps are filled.
Transcriptomic analysis of the cancer samples is frequently performed, often being a good starting point for the identification of novel biomarkers for a given cancer type.
When it is necessary to establish a threshold, that is, the clinical decision point, for a quantitative continuous biomarker, obtaining appropriate validation samples is frequently the rate limiting step in assay validation, so it is wise for the team to establish the strategy (purchase commercially or collaborate, e.g).
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However, dilute, large-volume biological samples are frequently encountered, especially in forensic or clinical laboratories.
The samples are frequently degraded and prone to contamination by DNA from other sources, and coaxing data out of the ancient material is costly and painstaking work.
Mass spectrometric detection is gradually replacing ultraviolet (UV) as the method of choice in bioanalysis, especially in the area of early drug discovery where high sensitivity and rapid sample throughput is required and where samples are frequently pooled or "cocktailed" prior to dosing or analysis.
Amon Tobin's sounds and samples are frequently used in the British car-based TV show Top Gear, and his song "Four Ton Mantis" has been used in a few of the more recent Nissan Qashqai and Juke advertisements.
The sensitivity of routine smear-microscopy is approximately 50% [2], culture techniques take several weeks to yield results, and suitable representative biological samples are frequently unobtainable either due to lack of sputum production or poor sample quality.
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CEO of Professional Science Editing for Scientists @ prosciediting.com