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An important aspect for future clinical application of such technology is that the potential biological signatures are suited to analyzing serial samples in longitudinal studies.
This could be accomplished in follow-up studies with patients' samples in longitudinal studies, or with isogenic breast cancer cells.
These findings should be viewed tentatively until findings are replicated with larger and more diverse samples, in longitudinal designs that employ controls.
Conversely, in the analysis of paired sera samples in longitudinal studies, seroprevalence was defined as proportion of individuals in the population that had a 2 unit of greater increase in log titre [ 8].
The sample size for the primary outcome (HR-QoL) was estimated by using the formula to test change in the mean of two normally distributed samples in longitudinal studies [ 50].
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However, in most studies, available measures of the earnings variable are current earnings in repeated cross-section samples or in longitudinal samples, and in practice, researchers have used short-run proxies of y it for long-run economic status variables of y i in time t, {kern125pt}y_{it}=lambda_{t}y_{i}+h text{Age}_{it})+nu_{it} (2).
a) Difference in the fall sample from the spring sample in longitudinal analysis (p < 0.05).
The attrition in the sample highlights the complexity of having a heterogeneous sample in longitudinal research.
First, our findings have to be confirmed in independent samples and in longitudinal studies.
Future work should attempt to replicate these wellbeing groups in other samples and in longitudinal as well as cross-sectional analyses.
Another limitation of our study design, as in any case control genetic association study, is the possibility of spurious associations, and thus these findings should be replicated in other large samples and in longitudinal studies.
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