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In addition, the AUC for CEA in our study is higher than those in the literature where they range from 0.69 to 0.79 [ 28– 31], which might be caused by samples in advanced stages or those including distant metastases.
Previous studies have tested ERCC1 mRNA expression in paraffin-embedded tumour samples in advanced colorectal cancer patients treated with 5-FU plus oxaliplatin (Shirota et al, 2001) and in non-small-cell lung cancer patients treated with gemcitabine plus cisplatin (Lord et al, 2002); both studies found a significant association between ERCC1 expression and survival.
Moreover, we distinguished and compared 14 samples in advanced AJCC stages III and IV in two categories: the former MCAM/MUC18 positive at t0 or later acquired during follow-up (eight patients) and the latter including patients who never showed MCAM/MUC18 (six patients).
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Hyal-1 and Hyal-2 were overexpressed in cancerous samples, especially in advanced stages of cancer.
Giant Trunade (Currently banned in advanced play).
Substitoad (Currently banned in advanced play).
One of the samples in the advanced stage clustered along with the early-stage samples and two advanced-stage samples clustered separately, and closer to early-stage cluster.
MMP 1, 2, 3, 8, and 13 expression levels were significantly elevated in advanced OA samples when compared to early OA samples, while also significantly elevated when compared to MMP 1, 2, 7, 8, 9, and 13 expression levels of normal synovial fluid samples.
Recent achievements in advanced sample preparation strategies, and the incorporation of alternative restraints, such as residual dipolar couplings,[ 1] and paramagnetic data[ 2] have overcome some of these limitations and provide a toolbox that can complement and, in some favourable cases, replace sparse NOE-based distance data.
Although histological characterization clearly demonstrated inflammatory processes at work in samples of advanced DN, RMA based array and gene ontology (GO) analysis could identify only limited regulation of GO categories associated with inflammation suggesting a more sensitive approach was needed [4].
Interestingly, we found reduced expression of these miRNAs in samples from advanced liver disease (LC and HCC) patients.
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