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Baseline lipoprotein concentration values are reported as those measured in plasma and the subsequent two samples in a trial were corrected for estimated changes in plasma volume from baseline using hematocrit (van Beaumont 1973).
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In our design, each gene in a chromosome corresponds to a particular sample in a trial.
In future work it will be critical to evaluate the ability of this assay to generate valid genomic predictions from prospectively collected FFPE samples in a clinical trial.
The strain-specific quantitative real-time PCR assays developed were suitable for identification and quantification of probiotic strains in human faecal samples in a controlled intervention trial.
It should be evaluated on a larger sample in a controlled trial.
It should be evaluated on a larger sample in a controlled trial JP interviewed all participants and communicated feedback to the treating medical teams.
We carried out an example of sample size determination first in a trial to show a difference between the new and control drug, and second in a trial to assess equivalence between two competing drugs.
However, when only 44 out of the planned 84 participants (52%) of the projected sample size is obtained in a trial, it is necessary to interpret the results cautiously.
All noise samples in each trial were independent samples with the same contrast (variance).
Our sample is drawn from former volunteers in a trial of postmenopausal hormone therapy and may not represent general populations.
Finally, we would stress the importance of a sample size calculation (with all its attendant assumptions), and that any such estimate is better than no sample size calculation at all, particularly in a trial protocol [ 36].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com