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Few historical environmental samples exist, and evidence that such strains made the jump to humans is even harder to come by.
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Notably, numerous publications about taxon and sequence sampling exist and considering this accumulated knowledge in these fields can help guide the search for homologous sequences.
Unfortunately, no tissue or DNA samples exist from these lines and any initial allelic frequency is potentially realistic for each of the four loci, leading to many possible initial scenarios.
Significant differences (P < 0.05) in elemental composition of soil, foliage and litter collected from between mineralized and background samples exist.
Two sources of divergence between training and validation samples exist: clinical differences such as diversity in cancer subtype, drug response, or prognosis, and genomic differences, or differences between gene expression patterns observed in the training and validation samples.
Junger has the elements of a classic mystery, though this one will never be solved, as everyone involved is long dead, and no DNA samples exist to prove or disprove anything.
Similarly, molecular profiling from FFPE material may be of great interest in the context of existing and newly planed clinical trials for which only formalin-fixed samples exist.
Two main rationales to detect LoF and Act driver genes acting across tumor samples exist.
At a more fundamental level, part of coming up with a research question requires determining whether the necessary samples even exist and, if so, where they are and how to get access to them.
Several suitable molecular methods for identifying market samples exist [reviewed in 20], [21].
Various morphologies result, whereby similarities between certain samples exist.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com