This technique increases the size of the 'overall sample' and ultimately enhances the statistical power of the analysis [33].
For the 3D case, they provide an insight on the development of plasticity through the sample, with an initial first phase leading to an homogeneous deformation, followed by a second phase where the deformation is more and more limited to the central sections of the sample and ultimately becomes localized, without the need for any initial defect or perturbation.
A novel method is presented for measuring solubility in supercritical CO2 (scCO2), which can be used in conjunction with traditional cloud point measurements to obtain information directly on the soluble portion of a given sample and, ultimately, a much more informative data set.
In order to avoid the pitfall of selection bias, consecutive inclusion of participants was conducted instead of relying on self-selection through the Internet, thereby increasing the representativeness of the sample, and ultimately, the validity of the results [ 4- 6].
Lack of a priori defined sample size calculations leading to insufficient sample sizes and ultimately insufficient statistical power [73]; studies with an insufficient sample size can thus lose their ethical justification [74].
The addition of a second site was desirable in order to increase the sample size and ultimately provide one of the largest women-only samples in CR research.
From a regulatory perspective, this evolutionary noise manifests as complexity on both the binding site and pathway level, which has significant impact on how we view, sample, create, and, ultimately, understand these important, yet enigmatic, systems.
Data from other neurological diseases suggest that optimising basic aspects of study process, such as improving classification of outcomes, can have a substantial impact on required sample size and ultimately cost of the study [ 37].
These results provide a basis for conducting further studies using human osteosarcoma cell lines or fresh osteosarcoma cells obtained from patient resection samples and such studies ultimately will provide a rationale for the preclinical/clinical evaluation of the antitumour activity of ZOL in combination with other anticancer agents.
Interpretation is influenced by sampling design and a priori designation of samples into replicate groups, and ultimately relies on the researcher's knowledge of the organisms and their environment.
