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More research with large samples and standardized diagnostic interviews is clearly warranted.
These trials, however [ 8– 10], included only 350 women in total and used only 7-day point prevalence of smoking abstinence as a primary outcome, leading authors to recommend replication in more robust designs, using larger samples and standardized assessments of continuous abstinence.
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Nine different definitions of IIV were computed for each sample, and standardized effect sizes (Cohen's d) were computed for each of these definitions in 500 simulated replicates using scores on the Mini Mental State Exam and Clock Drawing Test.
Expression values were log-transformed, quantile normalized to achieve the same expression value distribution for each sample, and standardized with Z-transformation across the samples.
f Coefficient of correlation (Pearson) between non-standardized biomarkers levels corrected for the case – control sampling and concentrations corrected for the case – control sampling and standardized for all sampling conditions excluding creatinine.
OD600 of the samples measured and standardized to 0.4.
For quality assurance, six biological replicate samples, blanks and standardized reference materials were included in all analyses.
Taken together, high standards of sampling quality and standardized sample preparation allow reliable data to be generated even with long term storage or repeated freeze-thaw cycles.
Strengths of this study include the international multicenter design, large sample size and standardized data collection.
The use of specificity designs, improved sampling strategies, and standardized, psychometrically strong measures in future research would greatly improve the quality of our knowledge on the interpersonal and family functioning of CSA survivors.
The strength of our study lies in its large sample size and standardized methodology.
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