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This report describes associations between molecular markers assessed in pretreatment tumor biopsy samples and response to neoadjuvant chemotherapy at the time of surgery, longer-term disease outcomes, and the relationship between response and RFS.
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The two surveys were not random samples and responses from the same participant were not linked.
The studies have similar study designs (population-based), sampling procedures (two-stage cluster or stratified random sampling) and response proportions (56 69%).
It is subject to the same sampling and response biases that can infect any survey, and because the survey was carried out by computer, it may underrepresent women with limited computer literacy.
Box Behnken sampling and response surface methods are adopted to obtain gradient information.
Numerical simulations are conducted on the most representative points selected using a computer experiment design method, which involves orthogonal Latin hypercube sampling and response model building.
Improvements to the sampling and response designs that emerged from this trial will benefit a full-scale accuracy assessment of the EOSD product and also provides insights for other regional and global land cover mapping programs.
Strengths of our study included sampling and response rate.
Sampling and response rate of the study are described in Figure 1.
The sampling and response rate have been published by Schäfer et al. [ 19].
Full details of the study sample and response rates have been described elsewhere [ 20].
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